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This multi-state binding model explains the endothermic phase as the states coordinating one or two histidine residues have a lower enthalpy of binding than those with three or four histidine residues coordinated

Intradermotherapy and Platelet-Rich Plasma A significant challenge in treating melasma is the low permeability of water-soluble substances through the hydrophobic layer of the stratum corneum

Acknowledgments The authors would like to thank Zhengliu Liang (College of Foreign Languages and Literature, Fudan University) for polishing the manuscript

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